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What is the Mesothelium?
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Mesothelioma affects the mesothelium. The mesothelium is a sac like membrane protecting many of our internal organs. The mesothelium has two layers of cells that allow the organs to move easily against other parts of the body. The mesothelium secretes a fluid for lubrication to stop any friction around the organs.
There are different names for the mesothelium for each organ:
Abdominal organs - peritoneum
Lungs - pleura
Heart - pericardium
Male internal reproductive organs - tunica vaginalis testis
Female reproductive organs - tunica serosa uteri
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Mesothelioma is cancer of the mesothelium. Mesothelium cell divide abnormally. Mesothelioma usually starts in the mesothelium of the lungs or abdominal organs (pleura or peritnoeum). Mesothelioma can also spread to neighboring organs and other parts of the body.
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Mesothelioma is still relatively rare. It can occur in men and woman of any age but it is most commonly occurring in men and the risk increases with age.
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Stages of Mesothelioma Development
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There are two systems in use that chart the development of Mesothelioma.
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The first is the Butchart system which is based on the size of the tumor; the second system is known as the TNM System which takes into consideration the size of the tumor, the spread and also if the lymph node has been affected.
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Butchart System
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Stage 1: There is Mesothelioma present in the right or left lung. It may also involve the diaphragm on the same side.
Stage 2: Mesothelioma has spread into the chest wall, esophagus, heart or both lungs.
Stage 3: Stage 3 of Mesothelioma is reached when the Mesothelioma has spread to the abdominal cavity.
Stage 4: Stage 4 is the final stage of mesothelioma. This is when the cancer has spread to other organs.
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TNM System
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Stage 1: The Mesothelioma involves either the left or right lung and potentially the pericardium and diaphragm on the same side.
Stage 2: When the Mesothelioma has spread from the left or right lung to the lymph node on the same side.
Stage 3: Stage 3 is when the Mesothelioma has spread to the chest wall, muscle, ribs, esophagus, heart or other organs on the same side.
Stage 4: Stage 4 is reached when the Mesothelioma has spread to the lymph nodes in the chest on the opposite side to the original tumor. At this stage, it may also have spread to the opposite lung, organs in the abdominal cavity or neck..

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